Monthly Archives: August 2015

Optimizing or troubleshooting LC?

Today I would like to introduce you to two books that I find very valuable and that can be freely downloaded from the internet. The “Five keys to successful LC methods” and “Controlling selectivity in reversed-phase LC” are collections of articles published in LC/GC in the section “LC Troubleshooting” by John W. Dolan. It’s useful […]

For practitioners: do you need weighted linear regression?

In my statistics course, similarly to I guess all other teachers concerned in calibration, I teach that for instrumental analyses weighted linear regression should be used. Why? Non-weighted linear regression (the one we can use with LINEST, SLOPE and INTERCEPT in excel) assumes same signal precision (repeatability standard deviation in other words) for all concentrations […]