Category Archives: Research

Prof. Susan D. Richardson Emerging Contaminants: State of the Art and New Discoveries

We are happy to invite you to the lecture by Prof. Susan D. Richardson on the topic of “Emerging Contaminants: State of the Art and New Discoveries” taking place on the 14th of August 2019. Follow the event on Facebook. Emerging Contaminants Environmental research continues to expand beyond traditional, regulated contaminants to emerging contaminants, such as […]

Ionization efficiency of an oligopeptide can be predicted based on its amino acid composition

Ionization efficiency of oligopeptides does depend on the chemical composition of the peptide. Longer oligopeptides generally obey higher ionization efficiency; however, for peptides containing more than seven amino acid the ionization efficiency values are relatively similar. Also, the ionization efficiency values of the amino acids can be used to estimate the ionization efficiency of a […]

We presented standard substance free quantitation in HPLC2019

Last Thursday the HPLC2019 meeting finished. The conference was this year held in Milano, Italy and incorporated more then 300 talks. I had a chance to give a keynote lecture on the quantification of metabolites from green tea with LC/MS without the need for standard substances. The main focus of the conference was on the […]

67th ASMS Conference on Mass Spectrometry and Allied Topics

From 1st to 6th of June, two PhD fellows Piia Liigand and I presented our recent results at 67th ASMS annual conference in Atlanta, USA. The conference was kicked off with a plenary lecture by Prof. Mark Z. Jacobson on the topic of “Transitioning the World Energy for All Purposes to Stable Electricity Powered by […]

Eurachem 2019 in Tartu was a success

Last week from 20th to 21th of May Tartu hosted Eurachem yearly workshop with the topic of “Validation of targeted and non-targeted methods of analysis”. These two days were filled with exciting presentations, insightful discussions and joy of meeting new and old friends and collaboration partners. What is happening in the field of non-targeted analysis? Eurachem […]

Mari submitted her master’s thesis on reactions in charged droplets

Today our master’s student Mari Ojakivi submitted her thesis. She studied the reactions between 7 aldehydes and 4 nitrogen bases in charged droplets. For this, she built an in-house built electrospray system to generate the charged droplets. Mostly imines were observed as reaction products, but also amides were found in some reactions. For comparison, the same reactions […]

Standard-substance-free quantification in LC/ESI/MS is finally here

We have now gathered our knowledge from years of ESI mechanism research and bundled it with data science to provide you with the possibility to quantify analytes in LC/ESI/MS analysis without the use of standard substances.   The availability of standard substances is one of the main limitations in LC/ESI/MS analysis, especially in the fields […]

New project: synthesis in charged droplets

At the end of last year, our group got very happy news from Estonian Research Council, we received the personal research funding team grant to investigate synthesis in charged droplets (project abbreviation SNT). This new and exciting project allowed us to widen our team. In addition to masters student Mari Ojakivi, already working on the topic, Andi […]

Optimization of flow splitting and make‐up flow conditions in liquid chromatography/electrospray ionization mass spectrometry

Recently a study in Rapid Communications in Mass Spectrometry was published. In this study, we optimized the actual split ratio and make-up flow composition in LC/ESI/MS analysis to increase the signal in radio detector and enhance the sensitivity of electrospray ionization. High methanol content increases electrospray ionization efficiency We studied make-up flow composition with a […]