From 27.-29. of September, I attended the Austrian Proteomics and Metabolomics Association (APMA) meeting in a breathtakingly beautiful Innsbruck, Tirol. The three days were filled with exciting talks on proteomics (my special focus was studies related to toxic effects) and different aspects of metabolomics (amino acids, xenobiotics, lipidomics). I was invited to give a keynote […]
Tag Archives: ESI
26
Oct
Oct
Last Tuesday Jon Sobus from EPA presented some of the findings from a recent paper Uncertainty estimation strategies for quantitative non-targeted analysis, where we were also happy to collaborate, on the BP4NTA online meeting. People from BP4NTA meetings have been reaching out with questions on ionization efficiency-based quantification. Some of these are often asked of us and I decided […]
10
Sep
Sep
How do you know which of the compounds detected in suspect or non-targeted screening is most likely to cause an adverse effect? Which is most toxic? Which is present in the highest concentration? Which is having a concentration close to a toxic endpoint? This is exactly what we are answering in our latest research in […]
25
Feb
Feb
Non-targeted screening with liquid chromatography-electrospray high-resolution mass spectrometry (LC/ESI/HRMS) is revealing hundred to thousands of contaminants in the water. We have recently proposed a way to quantify these contaminants based on the estimated LC/ESI/HRMS ionization efficiencies. But how to know how well such tools are performing? Well, we need to compare with classical methods that are […]
In June at HPLC conference I had a super nice possibility to explain what is non-targeted screening and why it should be developed into a quantitative method. Now, this video is available for all of you. I thank a lot Alasdair Matheson from LC&GC, who invited me to do the video, LCGC video teem, and HPLC […]
12
Nov
Nov
At the end of October, a three-day SWEMSA conference on non-targeted analysis took place in the Erding, close to Munich, Germany. On the conference representatives from different non-targeted communities came together to present the last progress made in the field. The focus was very strongly on the data analysis side but also method development and […]
27
Aug
Aug
Last week two of our PhD students, Piia Liigand and Jaanus Liigand, successfully defended their PhD theses. Both Piia and Jaanus worked intensively and successfully on understanding the ionization process in electrospray ionization source (ESI) and applying this knowledge for quantifying compounds with LC/ESI/MS without standard substances. Congratulations to the fresh doctors! Piia is continuing […]
22
Jul
Jul
Ionization efficiency of oligopeptides does depend on the chemical composition of the peptide. Longer oligopeptides generally obey higher ionization efficiency; however, for peptides containing more than seven amino acid the ionization efficiency values are relatively similar. Also, the ionization efficiency values of the amino acids can be used to estimate the ionization efficiency of a […]
24
Jun
Jun
Last Thursday the HPLC2019 meeting finished. The conference was this year held in Milano, Italy and incorporated more then 300 talks. I had a chance to give a keynote lecture on the quantification of metabolites from green tea with LC/MS without the need for standard substances. The main focus of the conference was on the […]
17
Jun
Jun
From 1st to 6th of June, two PhD fellows Piia Liigand and I presented our recent results at 67th ASMS annual conference in Atlanta, USA. The conference was kicked off with a plenary lecture by Prof. Mark Z. Jacobson on the topic of “Transitioning the World Energy for All Purposes to Stable Electricity Powered by […]
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